Self-emulsifying composition of OMEGA3 fatty acid
AssigneeMochida Pharmaceutical Co., Ltd.
InventorsHirosato Fujii, Motoo Yamagata
Life of this patent
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Abstract
This invention provides a self-emulsifying composition comprising 50 to 95% by weight in total of at least one compound selected from the group consisting of ω3 polyunsaturated fatty acids and their pharmaceutically acceptable salts and esters; and 5 to 50% by weight of an emulsifier having a hydrophilic lipophilic balance of at least 10. The composition has no or reduced ethanol content, and exhibits excellent self-emulsifying property, dispersibility in the composition, emulsion stability, and absorption property. The composition is adapted for use as a drug.
Claims13
A self-emulsifying composition comprising:
- (a) 50 to 95% by weight in total of at least one compound selected from the group consisting of eicosapentaenoic acid, docosahexaenoic acid, and their pharmaceutically acceptable salts and esters;
- (b) 3 to 40% by weight of a lecithin based on 100% by weight of said component (a);
- (c) 10 to 50% by weight of an emulsifier having a hydrophilic lipophilic balance (HLB) of at least 10 based on 100% by weight of said component (a), wherein the emulsifier is at least one selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene castor oil, polyethylene glycol fatty acid ester, and polyoxyethylene polyoxypropylene glycol;
- and
- (d) ethanol content is up to 4% or less by weight in relation to the total content.
A self-emtilsifying composition comprising;
- (a) 50 to 95% by weight in total of ethyl eicosapentaenoate ester;
- (b) 3 to 40% by weight of a lecithin based on 100% by weight of said component (a);
- (c) 10 to 50% by weight of an emulsifier having a HLB of at least 10 based on 100% by weight of said component (a), wherein the emulsifier is polyoxyethylene hydrogenated castor oil;
- (d) ethanol in a content of 0-4% by weight in relation to the total content;
- and
- (e) propylene glycol or glycerin.
Dependencies are inferred from the claim text.