Methods of attenuating cognitive deficits with sulfonyl fluorides
AssigneeBoard of Regents, The University of Texas System
InventorsCesario V. Borlongan, Donald E. Moss, Isabel C. Sumaya
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Abstract
The present invention provides for methods of treating cognitive deficits resulting from interruption of blood supply and/or oxygen deficit by administering a therapeutically effective dose of a sulfonyl fluoride, such as methanesulfonyl fluoride and ethanesulfonyl fluoride. The underlying cause of the or oxygen deficit can be from stroke, trauma, carbon monoxide poisoning, and other poisonings. This method also includes co-administering with sulfonyl fluoride with a therapeutically effective dose of a second agent.
Claims15
A method of treating a mammal for cognitive deficits resulting after an oxygen deficit in the brain comprising the step of administering to said mammal, within 24 hours of said deficit, a dose of a sulfonyl fluoride effective to treat said oxygen deficit in the brain, wherein said sulfonyl fluoride is selected from the group consisting of methanesulfonyl fluoride and ethanesulfonyl fluoride.
A method of reducing one or more stroke-induced cognitive deficits in a mammal comprising the step of administering to said mammal, within 24 hours of said stroke, a dose of a sulfonyl fluoride selected from the group consisting of methanesulfonyl fluoride and ethanesulfonyl fluoride, said dose effective to reduce one or more stroke-induced cognitive deficits.
A method of reducing stroke-induced loss of function in a tissue distal to the stroke site in a mammal comprising the step of administering to said mammal, within 24 hours of said stroke, a dose of a sulfonyl fluoride selected from the group consisting of methanesulfonyl fluoride and ethanesulfonyl fluoride, said dose effective to protect from stroke-induced loss of function at said distal tissue.
Dependencies are inferred from the claim text.