Derivatives of cycloalkyl- and cycloalkenyl-1,2-dicarboxylic acid compounds having formyl peptide receptor like-1 (FPRL-1) agonist or antagonist activity

A compound of the structure:

• wherein:
• a dashed line represents the presence or absence of a bond;
• each R1 is independently H, C1-C6 alkyl, C3-C8 cycloalkyl, or halide;
• R4 is H or C1-C6 alkyl;
• each R5 is independently H, C1-C6 alkyl, cycloalkyl, aryl, fused aryl, alkenyl, alkynyl, halide, hydroxy, alkoxy, trifluoromethyl, acetyl, —OCF3, —SCF3, nitroso, cyano, thioalkyl, —S(O)Me, —S(O)2Me, —S(O)2NH2, or —C(O)OR6, wherein R6 is H or C1-C6 alkyl;
• each X is independently C1-C6 alkyl, C1-C6 alkoxy, or each X taken together forms a cycloalkyl moiety, or each X taken together forms a substituted double bond;
• E1 is O or NH;
• E2 is O or NR7, wherein R7 is H or C1-C6 alkyl;
• n is 0-2;
• m is 0-5;
• and
• p is 1 or 2;
• or pharmaceutically acceptable salts, hydrates, solvates, tautomers, enantiomers, and diastereomers thereof.