LXR modulators

A compound, isotope, or pharmaceutically acceptable salt thereof, selected from the group consisting of:

• No.
• Name
• 1
• 2-(1-(3′-fluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-
• 2-(2-(2-fluorophenyl)propan-2-yl)-1H-imidazol-4-yl)propan-2-ol;
• 2
• 2-(2-(2-(2-chloro-6-fluorophenyl)propan-2-yl)-1-(3′-fluoro-4′-
• (hydroxymethyl)-3-methyl-5′-(methylsulfonyl)biphenyl-4-yl)-1H-
• imidazol-4-yl)propan-2-ol;
• 3
• 2-(1-(3-chloro-3′-fluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)bi-
• phenyl-4-yl)-2-(2-(2,6-dichlorophenyl)propan-2-yl)-1H-imidazol-4-
• yl)propan-2-ol;
• 4
• 2-(2-(2-(2-chloro-3-fluorophenyl)propan-2-yl)-1-(3′-fluoro-4′-
• (hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-
• yl)propan-2-ol;
• 5
• 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3′-fluoro-4′-(hydroxy-
• methyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-
• 2-ol;
• 6
• 2-(2-(2-(2-Chloro-phenyl)propan-2-yl)-1-(3,3′-difluoro-4′-hydroxy-
• methyl-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)-propan-
• 2-ol;
• 7
• 2-(2-(2-(2-chloro-6-fluorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-
• (hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-
• yl)propan-2-ol;
• 8
• 2-{1-(3,3′-Difluoro-4′-hydroxymethyl-5′-methanesulfonyl-biphenyl-
• 4-yl)-2-[2-(2-fluorophenyl)propan-2-yl]-1H-imidazol-4-yl}-propan-
• 2-ol;
• 9
• 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-
• (hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-
• 4-yl)propan-2-ol;
• 10
• 2-(2-(2-(2,6-dichlorophenyl)propan-2-yl)-1-(3,3′-difluoro-4′-
• (hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-
• yl)[(13CD3)2]propan-2-ol;
• 11
• 2-(2-(2,4-dichlorobenzyl)-1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-
• (methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol;
• 12
• 2-(1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-
• 4-yl)-2-(2-(trifluoromethyl)benzyl)-1H-imidazol-4-yl)propan-2-ol;
• 13
• 2-(1-(3-chloro-3′-fluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)bi-
• phenyl-4-yl)-2-(2-chloro-4-fluorobenzyl)-1H-imidazol-4-yl)propan-
• 2-ol;
• 14
• 2-(2-(2-chloro-4-fluorobenzyl)-1-(3,3′-difluoro-4′-(hydroxymethyl)-
• 5′-(methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol;
• 15
• 2-(2-(2,4-dichlorobenzyl)-1-(3′-fluoro-4′-(hydroxymethyl)-5′-
• (methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol;
• 16
• 2-(1-(3,3′-difluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-
• 4-yl)-2-(2-fluorobenzyl)-1H-imidazol-4-yl)propan-2-ol;
• 17
• 2-(1-(3′-fluoro-4′-(hydroxymethyl)-5′-(methylsulfonyl)biphenyl-4-
• yl)-2-(2-methylbenzyl)-1H-imidazol-4-yl)propan-2-ol;
• 18
• 2-(2-(2,6-dichlorobenzyl)-1-(3′-fluoro-4′-(hydroxymethyl)-5′-
• (methylsulfonyl)biphenyl-4-yl)-1H-imidazol-4-yl)propan-2-ol;
• 19
• 2-[2-(2-Chloro-5-fluoro-benzyl)-1-(3′-fluoro-4′-hydroxymethyl-5′-
• methanesulfonyl-biphenyl-4-yl)-1H-imidazol-4-yl]-propan-2-ol;
• 20
• 2-[2-(2-Chloro-benzyl)-1-(3,3′-difluoro-4′-hydroxymethyl-5′-
• methanesulfonyl-biphenyl-4-yl)-1H-imidazol-4-yl]-propan-2-ol;
• [[or]] and
• 21
• 2-{2-[1-(2,6-dichlorophenyl)ethyl]-1-[3,3′-difluoro-4′-(hydroxy-
• methyl)-5′-(methylsulfonyl)biphenyl-4-yl]-1H-imidazol-4-yl}propan-
• 2-ol.