Modified macrophage migration inhibitory factor inhibitors
AssigneeThe Feinstein Institute for Medical Research
InventorYousef Al-Abed
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Abstract
Provided are various compounds of Formula I (I). Also provided are various compounds of Formula II (II). Also provided are pharmaceutical compositions comprising the above compounds. Additionally, methods of inhibiting macrophage migration inhibitory factor (MIF) activity in a mammal are provided, as are methods of treating or preventing inflammation in a mammal. Further provided are methods of treating a mammal having sepsis, septicemia, and/or endotoxic shock. Also provided are methods of treating a mammal having an autoimmune disease, and methods of treating a mammal having a tumor.
Claims6
A compound having the structure:
- wherein R2, R3, R4 and R5 are independently F or H, wherein at least one of R2, R3, R4 and R5 is F and
- R is H or CH3.
Dependencies are inferred from the claim text.