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US 8,618,146 B2Granted
Epothilone compound formulations
AssigneeDr. Reddy's Laboratories, Inc.
InventorsChandrasekhar Kocherlakota, Tarun Singh, Nagaraju Banda, Prasad Vure, Aparna Mulupuru
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Abstract
The present application relates to compositions for parenteral administration of epothilone compounds, such as ixabepilone.
Claims14
A process for preparing a formulation of an epothilone compound having formula A,
- where R is hydrogen, or an alkyl, substituted alkyl, aryl, substituted aryl, or heterocyclic group, including any salts and any stereoisomers of the compounds or salts, comprising:
- a) dissolving the epothilone compound in a mixture of at least 20% by volume tertiary-butanol and acetone or acetonitrile;
- b) drying the solution at about −80° C. to about 40° C. under vacuum from about 5 millitorr to about 250 millitorr, to form a primary lyophilized product;
- and
- c) drying the primary lyophilized product at about 10° C. to about 30° C. under vacuum from about 5 millitorr to about 300 millitorr, to provide a lyophilized product of the epothilone compound.
2 more elements
A process for preparing a formulation of ixabepilone, comprising:
- a) dissolving ixabepilone in a mixture of at least 20% by volume tertiary-butanol and acetone or acetonitrile;
- b) drying the solution at about −80° C. to about 40° C. under vacuum from about 5 millitorr to about 250 millitorr, to form a primary lyophilized product;
- and
- c) drying the primary lyophilized product at about 10° C. to about 30° C. under vacuum from about 5 millitorr to about 300 millitorr, to provide a lyophilized product.
1 more element
Dependencies are inferred from the claim text.