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US 8,618,143 B1Granted
Selective neuronal nitric oxide synthase inhibitors with azole substituents
AssigneeNorthwestern University
InventorsRichard B. Silverman, James M. Kraus
Life of this patent
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Abstract
Non-peptide, azole-substituted nitric oxide snythase inhibitor compounds, compositions and related methods, as can be used to enhance bioavailability and inhibit production of nitric oxide.
Claims19
A compound selected from compounds of a formula
- wherein X, Y and Z are independently selected from CR1, CH2, O, S, N and NR2 moieties;
- each said R1 is independently selected form H, alkyl and halo moieties and a covalent bond to said ethanamine moiety;
- and each said R2 is independently selected from H and alkyl moieties;
- and salts thereof.
1 more element
A compound selected from compounds of a formula
- wherein X, Y and Z are independently selected from CR1, CH2, O, S, N and NR2 moieties;
- each said R1 is selected from H and alkyl moieties;
- and each said R2 is independently selected from H and alkyl moieties;
- and salts thereof.
1 more element
A method of inhibiting a nitric oxide synthase comprising contacting a nitric oxide synthase with an effective amount of a compound of a formula
- wherein X, Y and Z are independently selected from CRi, CH2, O, S, N and NR2 moieties;
- each said R1 is selected from H and alkyl moieties;
- and each said R2 is independently selected from H and alkyl moieties;
- and salts thereof.
1 more element
Dependencies are inferred from the claim text.