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US 8,618,139 B2Granted
Oxadiazole derivatives as sphingosine 1-phosphate (S1P) receptor modulators
AssigneeAllergan, Inc.
InventorsWenkui K. Fang, Liming Wang, Evelyn G. Corpuz, Ken Chow, Wha Bin Im
Life of this patent
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Abstract
The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
Claims12
A compound having Formula I, its enantiomers, diastereoisomers, tautomers or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- R2 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- R3 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- R4 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- R5 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- R6 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- R7 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- R8 is H, halogen, —OC1-8 alkyl, C1-8 alkyl, CN, C(O)R11, NR12R13 or hydroxyl;
- L is O, S or NH;
- R11 is H or C1-8 alkyl;
- R12 is H or C1-8 alkyl;
- R13 is H or C1-8 alkyl;
- R14 is H, C1-6 alkyl or C3-6 cycloalkyl;
- and
- R15 is H, C1-6 alkyl or C3-6 cycloalkyl.
13 more elements
Dependencies are inferred from the claim text.