Indole amide derivatives and related compounds for use in the treatment of neurodegenerative diseases

A compound of structural formula (A5), or a stereoisomer, enantiomer, or tautomer thereof,

• wherein,
• R5 is selected from the group consisting of halogen;
• —OH;
• —OR10;
• —SH;
• —SR10;
• —S(O)R11;
• —S(O)2R11;
• —SO2NR12R13;
• trifluoromethyl;
• trifluoromethoxy;
• nitro;
• —NHC(O)R10;
• —NHS(O)2R10;
• —NHC(O)NR12R13;
• —NR10C(O)R10;
• —NR10S(O)2R10;
• —NR10C(O)NR12R13;
• —NR12R13;
• -cyano;
• —COOH;
• —COOR10;
• —C(O)NR12R13;
• —C(O)R11;
• alkyl;
• alkenyl;
• alkynyl;
• aryl;
• heterocycle;
• arylalkylene;
• arylalkenylene;
• arylalkynylene;
• heterocycle-alkylene;
• heterocycle-alkenylene;
• and heterocycle-alkynylene;
• L is a single bond or is independently selected from the group consisting of —O—;
• —NH—;
• —NR10—;
• C1-6alkylene;
• C1-6alkenylene;
• and C1-6alkynylene, wherein each of said C1-6alkylene, C1-6alkenylene or C1-6alkynylene optionally includes one or more heteroatoms, said heteroatoms being selected from the heteroatoms consisting of S and N, and wherein each of said C1-6alkylene, C1-6alkenylene or C1-6alkynylene, can be unsubstituted or substituted;
• and wherein a carbon atom or heteroatom of said C1-6alkylene, C1-6alkenylene or C1-6alkynylene, can be oxidized to form a C═O, C═S, N═O, N═S, S═O or S(O)2;
• B is cyclic structure selected from the group consisting of cycloalkyl;
• cycloalkenyl;
• cycloalkynyl;
• aryl;
• and heterocycle;
• R8 is independently selected from the group consisting of hydrogen;
• halogen;
• alkyl;
• alkenyl;
• alkynyl;
• —OH;
• —OR10;
• —SH;
• —SR10;
• —S(O)R11;
• —S(O)2R11;
• —SO2NR12R13;
• trifluoromethyl;
• trifluoromethoxy;
• nitro;
• —NHC(O)R10;
• —NHS(O)2R10;
• —NHC(O)NR12R13;
• —NR10C(O)R10;
• —NR10S(O)2R10;
• —NR10C(O)NR12R13;
• —NR12R13;
• -cyano;
• —COOH;
• —COOR10;
• —C(O)NR12R13;
• and —C(O)R11;
• m is selected from the group consisting of 0;
• 1;
• 2;
• 3;
• 4 and 5;
• each R10 is independently selected from the group consisting of alkyl;
• alkenyl;
• alkynyl;
• aryl;
• heterocycle;
• arylalkylene;
• arylalkenylene;
• arylalkynylene;
• heterocycle-alkylene;
• heterocycle-alkenylene;
• and heterocycle-alkynylene;
• each R11 is independently selected from the group consisting of hydroxyl;
• alkyl;
• alkenyl;
• alkynyl;
• aryl;
• heterocycle;
• arylalkylene;
• arylalkenylene;
• arylalkynylene;
• heterocycle-alkylene;
• heterocycle-alkenylene;
• and heterocycle-alkynylene;
• each R12 and R13 is independently selected from the group consisting of hydrogen;
• alkyl;
• alkenyl;
• alkynyl;
• aryl;
• heterocycle;
• arylalkylene;
• arylalkenylene;
• arylalkynylene;
• heterocycle-alkylene;
• heterocycle-alkenylene;
• and heterocycle-alkynylene;
• or wherein R12 and R13 are taken together to form a 5-, 6-, or 7-membered unsubstituted or substituted heterocycle;
• or a solvate, hydrate, salt or prodrug thereof,
• wherein the compound is not 3-isoxazolecarboxamide, 5-(4-chlorophenyl)-N-[2-(5-methyl-1H-indol-3-yl)ethyl]-.