Methods for the treatment of myeloproliferative diseases using 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione
AssigneeCelgene Corporation
InventorJerome B. Zeldis
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Abstract
Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and/or the transplantation of blood or cells. Particular second active agents are capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of a myeloproliferative disease. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
Claims26
A method of treating myelofibrosis with myeloid metaplasia, which comprises administering to a patient having myelofibrosis with myeloid metaplasia from about 0.1 to about 2.0 mg per day of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione, or a pharmaceutically acceptable salt or stereoisomer thereof.
A method of treating myelofibrosis with myeloid metaplasia, which comprises administering to a patient having myelofibrosis with myeloid metaplasia about 0.1 mg per day of 4-(amino)-2-(2,6-dioxo(3-piperidyl))-isoindoline-1,3-dione.
Dependencies are inferred from the claim text.