Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
AssigneeThe Trustees of the University of Pennsylvania
InventorDaniel J. Rader
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Abstract
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the MTP inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.
Claims10
A method of treating a subject suffering from hyperlipidemia or hypercholesterolemia, the method comprising administering to the subject an effective amount of an MTP inhibitor, wherein said administration comprises at least three step-wise, increasing dose levels of the MTP inhibitor wherein a first dose level is from about 2 to about 13 mg/day, a second dose level is from about 5 to about 30 mg/day, and a third dose level is from about 10 to about 50 mg/day;
- and wherein the MTP inhibitor is represented by:
- or a pharmaceutically acceptable salt thereof or the piperidine N-oxide thereof, and wherein each dose level is administered to the subject for about 1 to about 5 weeks.
A method of treating a subject suffering from hyperlipidemia or hypercholesterolemia, the method comprising administering to the subject an effective amount of an MTP inhibitor, wherein said administration comprises at least three step-wise, increasing dose levels of the MTP inhibitor wherein a first dose level is from about 2 to about 13 mg/day, administered to the subject for about 2 weeks;
- a second dose level is from about 5 to about 30 mg/day, administered to the subject for about 2 weeks to about 4 weeks;
- and a third dose level is from about 10 to about 50 mg/day, administered to the subject for about 2 weeks to about 4 weeks;
- and wherein the MTP inhibitor is represented by:
- or a pharmaceutically acceptable salt thereof or the piperidine N-oxide thereof.
A method of treating a subject suffering from hyperlipidemia or hypercholesterolemia, the method comprising administering to the subject an effective amount of an MTP inhibitor, wherein said administration comprises at least three step-wise, increasing dose levels of the MTP inhibitor wherein a first dose level is from about 2 to about 13 mg/day, administered to the subject for about 1 to about 12 weeks;
- a second dose level is from about 5 to about 30 mg/day, administered to the subject for about 4 weeks;
- and a third dose level is from about 10 to about 50 mg/day, administered to the subject for about 4 weeks;
- and wherein the MTP inhibitor is represented by:
- or a pharmaceutically acceptable salt thereof or the piperidine N-oxide thereof.
Dependencies are inferred from the claim text.