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US 8,618,133 B2Granted
Aralkyl alcohol pyridine derivative compounds and the use thereof as medicaments for treating depression
AssigneeJiangsu Hengyi Pharmaceutical Co., Ltd.
InventorsJianqi Li, Kai Gao, Wangping Cai, Yongyong Zheng
Life of this patent
Estimating the term…
Abstract
The present invention relates to an aralkyl alcohol piperidine derivative and use as antidepressant thereof. The said aralkyl alcohol piperidine derivative has a triple inhibition effect on the reuptaking of 5-HT, NA and DA. The derivative may be administered to the patient in need of such treatment in the form of composition by oral administration, injection and the like. The derivative is a compound having the following general formula or its salt:
Claims5
A compound or a tree base or a salt thereof selected from:
- V-1 Threo-4-benzyl-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-2 Erythro-4-benzyl-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-5 Threo-4-benzyl-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-6 Erythro-4-benzyl-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-11 Threo-4-(4-fluorobenzyl)-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine,
- V-12 Erythro-4-(4-fluorobenzyl)-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-13 Threo-4-benzyl-4-hydroxy-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-14 Erythro-4-benzyl-4-hydroxy-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-15 Threo-4-benzyl-4-hydroxy-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-16 Erythro-4-benzyl-4-hydroxy-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-21 Threo-4-(4-chlorobenzyl)-4-hydroxy-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-22 4-(4-chlorobenzyl)-4-hydroxy-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-23 Threo-4-(4-fluorobenzyl)-4-hydroxy-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-24 Erythro-4-(4-fluorobenzyl)-4-hydroxy-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-25 Threo-4-(3,4-dichlorobenzyl)-methylene-N-[1-methyl-2-hydroxy-2-(5-chloro-(6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-26 Erythro-4-(3,4-dichlorobenzyl)-methylene-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-29 Threo-4-(3,4-dichlorobenzyl)-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-30 4-(3,4-dichlorobenzyl)-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-31 4-benzyl-methylene-N-[2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-32 4-benzyl-methylene-N-[3-hydroxy-3-(5-chloro-6-methoxynaphthalene-2-yl)]propylpiperidine;
- V-33 Threo-4-(4-fluorobenzyl)-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-34 Erythro-4-(4-fluorobenzyl)-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-(6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-35 Threo-4-(4-chlorobenzyl)-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-36 Erythro-4-(4-chlorobenzyl)-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-37 Threo-4-benzyl-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-38 Erythro-4-benzyl-methylene-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethylpiperidine;
- V-39 Threo-4-benzyl-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethyl-1,2,3,6-tetrahydropyridine;
- V-40 Erythro-4-benzyl-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethyl-1,2,3,6-tetrahydropyridine;
- V-43 Threo-4-benzyl-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethyl-1,2,3,6-tetrahydropyridine;
- V-44 Erythro-4-benzyl-N-[1-ethyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethyl-1,2,3,6-tetrahydropyridine;
- V-47 Threo-4-(4-fluorobenzyl)-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethyl-1,2,3,6-tetrahydropyridine;
- V-48 Erythro-4-(4-fluorobenzyl)-N-[1-methyl-2-hydroxy-2-(5-chloro-6-methoxynaphthalene-2-yl)]ethyl-1,2,3,6-tetrahydropyridine.
29 more elements
Dependencies are inferred from the claim text.