Fused cyanopyridines and the use thereof

A compound of the formula (I)

• in which
• ring Q represents a group of the formula
• where
• * represents in each case the point of attachment to the C2 atom,
• # represents in each case the point of attachment to the C3 atom,
• R3 represents hydrogen or (C1-C4)-alkyl,
• R4 represents hydrogen or (C1-C4)-alkyl,
• R5 represents hydrogen, (C1-C4)-alkyl or amino,
• R6 represents in each case hydrogen, (C1-C4)-alkyl or allyl,
• in which (C1-C4)-alkyl may be substituted by a substituent selected from the group consisting of hydroxycarbonyl, (C1-C4)-alkoxycarbonyl and amino,
• R7 represents in each case hydrogen, (C1-C4)-alkyl, trifluoromethyl, amino, mono-(C1-C4)-alkylamino or di-(C1-C4)-alkylamino,
• in which (C1-C4)-alkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of hydroxyl, methoxy and amino, and either
• i) R8A represents in each case hydrogen, hydroxyl, (C1-C4)-alkoxy or mono-(C1-C4)-alkylamino,
• in which (C2-C4)-alkoxy and mono-(C2-C4)-alkylamino may be substituted by a hydroxyl substituent,
• and
• R8B represents hydrogen,
• or
• R8A together with R8B forms an oxo, N—(C1-C4)-alkylimino, N—(C1-C4)-alkoxyimino or (C1-C4)-alkoxycarbonylmethylidene group,
• and
• R9A and R9B independently of one another represent in each case hydrogen or (C1-C4)-alkyl or together with the carbon atom to which they are attached form a spiro-linked 3-to 5-membered cycloalkyl ring,
• and
• R10 represents hydrogen, (C1-C4)-alkyl or phenyl,
• in which (C1-C4)-alkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of hydroxyl and amino,
• X represents S or O,
• R1 represents a 5- to 10-membered heteroaryl,
• where (C6-C10)-aryl and 5- to 10-membered heteroaryl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, trifluoromethyl, hydroxyl, (C1-C6)-alkoxy, amino, mono-(C1-C6)-alkylamino, di-(C1-C6)-alkylamino, hydroxycarbonyl, (C1-C6)-alkoxycarbonyl, aminocarbonyl, mono-(C1-C6)-alkylaminocarbonyl, di-(C1-C6)-alkylaminocarbonyl, pyrrolidino, piperidino, morpholino, piperazino and N′-(C1-C4)-alkylpiperazino, phenyl and 5- or 6-membered heteroaryl,
• in which phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, nitro, cyano, (C1-C6)-alkyl, difluoromethyl, trifluoromethyl, hydroxyl, (C1-C6)-alkoxy, difluoromethoxy, trifluoromethoxy, amino, mono-(C1-C6)-alkylamino, di-(C1-C6)-alkyl-amino, hydroxycarbonyl and (C1-C6)-alkoxycarbonyl,
• R2 represents (C5-C6)-cycloalkyl, 5- or 6-membered heterocyclyl, phenyl or 5- or 6-membered heteroaryl,
• where (C5-C6)-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C6)-alkyl, hydroxyl, oxo, (C1-C6)-alkoxy, amino, mono-(C1-C6)-alkylamino and di-(C1-C6)-alkylamino,
• in which (C1-C6)-alkyl and (C1-C6)-alkoxy may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of hydroxyl, (C1-C4)-alkoxy and (C3-C7)-cycloalkyl,
• in which (C3-C7)-cycloalkyl for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy,
• and
• where 5- or 6-membered heterocyclyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of oxo, thioxo, hydroxyl, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylcarbonyl, amino, mono-(C1-C6)-alkylamino, di-(C1-C6)-alkylamino and (C3-C7)-cycloalkyl,
• in which (C1-C6)-alkyl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, oxo, hydroxyl, trifluoromethyl, (C1-C4)-alkoxy, (C1-C4)-alkylcarbonyloxy, amino, mono-(C1-C4)-alkylamino, di-(C1-C4)-alkylamino and (C3-C7)-cycloalkyl,
• in which (C3-C7)-cycloalkyl for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy,
• and
• in which (C1-C6)-alkylcarbonyl may be substituted by a substituent selected from the group consisting of hydroxyl and (C1-C4)-alkoxy,
• and
• in which (C3-C7)-cycloalkyl may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy,
• and
• where phenyl and 5- or 6-membered heteroaryl may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of halogen, cyano, hydroxyl, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C3-C7)-cycloalkoxy and —NRARB,
• in which (C1-C6)-alkyl may be substituted by 1 to 3 substituents selected from the group consisting of fluorine,
• and
• in which (C1-C6)-alkoxy may be substituted by 1 to 3 substituents independently of one another selected from the group consisting of fluorine, trifluoromethyl, (C3-C7)-cycloalkyl, oxo, hydroxyl, (C1-C4)-alkoxy, hydroxycarbonyl, amino, mono-(C1-C4)-alkylamino and di-(C1-C4)-alkylamino,
• and
• in which (C3-C7)-cycloalkoxy may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy,
• and
• in which
• RA represents hydrogen or (C1-C6)-alkyl,
• in which (C1-C6)-alkyl for its part may be substituted by a substituent selected from the group consisting of hydroxyl and (C1-C4)-alkoxy,
• RB represents hydrogen, (C1-C6)-alkyl, (C3-C7)-cycloalkyl, (C1-C4)-alkylsulfonyl or (C3-C7)-cycloalkylsulfonyl,
• in which (C1-C6)-alkyl for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C3-C7)-cycloalkyl, oxo, hydroxyl, (C1-C4)-alkoxy, hydroxycarbonyl, amino, mono-(C1-C4)-alkylamino and di-(C1-C4)-alkylamino,
• and
• in which (C3-C7)-cycloalkyl for its part may be substituted by 1 or 2 substituents independently of one another selected from the group consisting of (C1-C4)-alkyl, hydroxyl, oxo and (C1-C4)-alkoxy,
• or
• in which two adjacent substituents at the phenyl together with the carbon atoms to which they are attached may form a 1,3-dioxolane or 2,2-difluoro-1,3-dioxolane, or an N-oxide, salt, or salt of the N-oxide thereof,
• except for the compounds 5,6,7,8-tetrahydro-2-[[(2-methylphenyl)methyl]thio]-4-(2-thienyl)-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[(2-phenylmethyl)thio]-4-(2-thienyl)-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[[(2-methylphenyl)methyl]thio]-4-(4-pyridyl)-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[(phenylmethyl)thio]-4-phenyl-3-quinolinecarbonitrile, 5,6,7,8-tetrahydro-2-[(phenylmethyl)thio]-4-(4-chlorophenyl)-3-quinolinecarbonitrile, 6,7-dihydro-4-(4-hydroxyphenyl)-2-[(phenylmethyl)thio]-5H-cyclopentapyridine-3-carbonitrile.