Deuterium-enriched pyrimidine compounds and derivatives
OwnerDaljit Singh Dhanoainventor
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Abstract
The present invention is concerned with deuterium-enriched pyrimidine compounds of formula I, their derivatives and pharmaceutically acceptable salts and methods of use thereof for the treatment of pulmonary arterial hypertension, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis, hypertension, ischemic stroke, angina pectoris, congestive heart failure, arrhythmia, arterial fibrillation, Alzheimer's disease, cognition impairment, memory decline, and schizophrenia, and depression.
Claims11
A deuterium-enriched compound of formula 1,
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is Cl;
- R2 is independently selected from H, D, F or Cl;
- R3 is independently selected from H or D;
- R4 and R5 are independently selected from D or H;
- R6, R7, R8, R9 and R10 are independently selected from D, H, F, Cl or CN;
- R11, R12, R13, R14, R15, R16, R17, R18, and R19 are independently selected from D or H;
- and
- R20 is selected from D or H.
A deuterium enriched compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
Dependencies are inferred from the claim text.