Compositions and methods for apoptosis modulators

A compound of a structural Formula (III):

• or a salt, solvate, or prodrug thereof;
• wherein:
• q is 3;
• X and Y are O;
• J, K, L and M are independently CR25 or N;
• R22 is substituted cycloheteroalkyl comprising a substituent selected from the group consisting of aryl, substituted aryl, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, cycloalkyldiyl, substituted cycloalkydiyl, cycloheteroalkyldiyl, substituted cycloheteroalkyldiyl, and hydroxyl;
• R25 is halo, cyano, nitro, hydrogen, OR26, S(O)tR26, CO2R26, CONR26R27 or NR26R27, alkyl, substituted alkyl, heteroalkyl or substituted heteroalkyl, wherein t is 0, 1, or 2;
• each R26 and R27 are independently hydrogen, alkyl, substituted alkyl, cycloheteroalkyl, substituted cycloheteroalkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heteroaryl, substituted heteroaryl, heteroarylalkyl, substituted heteroarylalkyl, heteroalkyl or substituted heteroalkyl;
• or alternatively, R26 and R27, taken together with the atoms to which they are bonded, form a cycloheteroalkyl or substituted cycloheteroalkyl ring;
• and
• with the proviso that Formula (III) does not include
• 1-[3-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)propyl]-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dione 2-oxide.