Hypotensive lipid and timolol compositions and methods of using same
AssigneeAllergan, Inc.
InventorsJune Chen, David F. Woodward, Alexander B. Kharlamb
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Abstract
New compositions for and methods of treating ocular hypertension provide for effective treatment of ocular hypertension often using reduced concentrations of active components. Such compositions include a timolol component and a hypotensive lipid component. The present compositions and methods are relatively straightforward, can be easily produced, for example, using conventional manufacturing techniques, and can be easily and conveniently practiced, for example, using application or administration techniques or methodologies which are substantially similar to those employed with prior compositions used to treat ocular hypertension.
Claims12
A method of treating ocular hypertension which comprises administering to an eye a composition comprising about 0.5% (w/v) timolol or pharmaceutically acceptable salts thereof, and about 0.03% (w/v) of cyclopentane N-ethyl heptenamide-5-cis-2-(3-α-hydroxy-5-phenyl-1-trans-pentenyl)-3-,5-dihydroxy,[1α,2β,3α,5α] wherein said composition produces at least one reduced side effect relative to a second composition comprising the same amount of cyclopentane N-ethyl heptenamide-5-cis-2-(3-α-hydroxy-5-phenyl-1-trans-pentenyl)-3-,5-dihydroxy,[1α,2β,3α,5α] without said timolol.
A method of treating ocular hypertension which comprises administering to an eye a liquid composition comprising about 0.5% (w/v) timolol, and about 0.03% (w/v) cyclopentane N-ethyl heptenamide-5-cis-2-(3-α-hydroxy-5-phenyl-1-trans-pentenyl)-3-,5-dihydroxy, [1α,2β,3α,5α], 0.005% (w/v) benzalkonium chloride, wherein said composition is an aqueous solution, wherein said composition produces at least one reduced side effect relative to a second composition including the same amount of cyclopentane N-ethyl heptenamide-5-cis-2-(3-α-hydroxy-5-phenyl-1-trans-pentenyl)-3-,5-dihydroxy,[1α,2β,3α,5α] without said timolol.
Dependencies are inferred from the claim text.