Inhibitors of the plasmodial surface anion channel as antimalarials
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsSanjay A. Desai, Ajay D. Pillai
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Abstract
Disclosed are inhibitors of the plasmodial surface anion channel (PSAC) inhibitors and the use thereof in treating or preventing malaria in an animal such as a human, comprising administering an effective amount of an inhibitor or a combination of inhibitors. An example of such an inhibitor is a compound of formula I, Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R7 are as described herein.
Claims22
A method of providing prophylaxis to an animal against malaria or treating an animal afflicted with malaria comprising administering to the animal:
- (i) an effective amount of a compound of formula I:
- wherein R1 is hydrogen or alkyl and R2 is arylalkyl, optionally substituted on the aryl with one or more substituents selected from the group consisting of halo, hydroxyl, nitro, cyano, amino, alkyl, aminoalkyl, alkylamino, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, and formyl;
- or R2 is a group of formula (II):
- wherein n=0 to 6;
- or R1 and R2 together with the N to which they are attached form a heterocycle of formula III:
- wherein X is N or CH;
- and
- Y is aryl, alkylaryl, dialkylaryl, arylalkyl, alkoxyaryl, or heterocyclic, optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, nitro, cyano, amino, aminoalkyl, alkylamino, alkylcarbonyl, alkoxycarbonyl, aminocarbonyl, and formyl;
- and
- R3-R10 are hydrogen or alkyl;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.