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US 8,618,089 B2Granted
Substituted porphyrins
AssigneeDuke University
InventorsInes Batinic-Haberle, Irwin Fridovich, Ivan Spasojevic
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Abstract
Substituted metalloporphyrin compounds are described, along with pharmaceutical compositions containing the same, and methods of use thereof in protecting cells from oxidant-induced toxicity and pathological conditions such as inflammatory lung disease, neurodegenerative conditions, radiation injury, cancer, diabetes, cardiac conditions and sickle cell disease. Mn(III) porphyrins bearing oxygen atoms within side chains are particularly described.
Claims12
A compound of the formula:
- wherein each R is —(CH2)mCH2OX, wherein
- m is 1 or 2;
- X is C1-6 alkyl (straight chain or branched),
- each A is independently selected from the group consisting of H, halo, NO2 and CHO,
- M is a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel and zinc, and
- Z− is a counterion.
3 more elements
Dependencies are inferred from the claim text.