Therapeutic formulations of desoxyepothilones
AssigneeKoasn Biosciences Incorporated
InventorsPeter J. Licari, Ziyang Zhong, Indu Isaacs, John G. Augustine
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Abstract
Formulations of desoxyepothilones are stable before and after dilution into aqueous media.
Claims15
A pharmaceutical composition comprising a homogeneous solution of a desoxyepothilone together with a pharmaceutically acceptable carrier, wherein said pharmaceutically acceptable carrier comprises ethanol at between about 40% and about 70%, glycerol at between about 5% and about 15%, PEG 400 at between about 10% and about 40%, and polysorbate 80 at between about 5% and about 15%, wherein said desoxyepothilone is present at between about 0.1 mg/mL and about 100 mg/mL, and wherein the pharmaceutical composition provides physically and chemically stable solutions before and after dilution into aqueous medium.
A pharmaceutical composition comprising a homogeneous solution of a desoxyepothilone together with a pharmaceutically acceptable carrier, wherein said pharmaceutically acceptable carrier comprises ethanol at between about 40% and about 70%, propylene glycol at between about 5% and about 15%, PEG400 at between about 10% and about 40%, and polysorbate 80 at between about 5% and about 15%, wherein said desoxyepothilone is present at between about 1 mg/mL and about 100 mg/mL, and wherein the pharmaceutical composition provides physically and chemically stable solutions before and after dilution into aqueous medium.
A pharmaceutical composition comprising a homogeneous solution of a desoxyepothilone together with a pharmaceutically acceptable carrier, wherein said pharmaceutically acceptable carrier comprises ethanol at between about 40% and about 70%, PEG400 at between about 10% and about 40%, and Solutol HS-15 at between about 10% and about 30%, wherein said desoxyepothilone is present at between about 1 mg/mL and about 100 mg/mL, and wherein the pharmaceutical composition provides physically and chemically stable solutions before and after dilution into aqueous medium.
Dependencies are inferred from the claim text.