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US 8,618,084 B2Granted
Aldosterone induced vascular elastin production
AssigneesHuman Matrix Sciences, LLC, The Hospital for Sick Children
InventorsAleksander Hinek, Thomas F. Mitts
Life of this patent
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Abstract
Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.
Claims7
A method for increasing the net deposition of elastin in a post-infarcted heart comprising:
- administering an effective amount of the mineralocorticoid aldosterone, and an effective amount of the collagen inhibitor spironolactone to a subject in need thereof.
Dependencies are inferred from the claim text.