Compositions, gels and foams with rheology modulators and uses thereof

A therapeutic composition comprising:

• a first rheology modulator comprising a pharmaceutical or a cosmetic active agent at least part of which is suspended in the therapeutic composition;
• and
• a carrier comprising:
• a) a second rheology modulator selected from the group consisting of (i) a combination of at least one fatty alcohol and at least one wax;
• (ii) a combination of at least one fatty acid and at least one wax;
• and (iii) a combination of:
• at least one fatty alcohol, at least one fatty acid, and at least one wax;
• and
• b) at least one hydrophobic solvent;
• the carrier being otherwise free of or containing less than 0.1% by weight of surfactant;
• wherein the at least one wax comprises a hydrogenated castor oil;
• wherein the viscosity of the therapeutic composition is at least about 30% higher than the viscosity of a first partial composition comprising the carrier without the first rheology modulator;
• and is higher than the viscosity of the first rheology modulator and the at least one hydrophobic solvent without the second rheology modulator;
• and
• wherein the viscosity of the first partial composition is less than about 25,000 cPs at room temperature.