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US 8,618,079 B2Granted
Imidazo[1,2-a] pyridinyl bisphosphonates
AssigneeIsis Innovation Limited
InventorsFrank Hallock Ebetino, Adam Mazur, Mark Walden Lundy, Robert Graham Russell
Life of this patent
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Abstract
Novel imidazo[1,2-α]pyridinyl bisphosphonate compounds are disclosed, as well as methods of preparing the compounds, pharmaceutical compositions including the compounds, and administration of the compounds in methods of treating abnormal calcium and phosphate metabolism, including bone and joint diseases and other disorders.
Claims18
A compound, or a pharmaceutically acceptable salt thereof, wherein the compound has a structure according to Formula I
- wherein:
- R1 is hydrogen, hydroxyl, lower alkyl, methoxy, or F;
- R2 is hydrogen, hydroxyl, lower alkyl, or F;
- and
- R3 is F, CI, or hydrogen.
2 more elements
A pharmaceutical composition comprising:
- a compound, or a pharmaceutically acceptable salt thereof, wherein the compound has a structure according to Formula I
- wherein:
- R1 is hydrogen, hydroxyl, lower alkyl, methoxy, or F;
- R2 is hydrogen, hydroxyl, lower alkyl, or F;
- and
- R3 is F, CI, or hydrogen;
- and
- a pharmaceutically acceptable carrier.
5 more elements
Dependencies are inferred from the claim text.