Certain compounds, compositions and methods
AssigneeEisai Co., Ltd.
InventorsGregory S. Hamilton, Takashi Tsukamoto, Dana V. Ferraris, Bridget Duvall, Rena Lapidus
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Abstract
The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds.
Claims20
A kit comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof:
- wherein the carbon marked by an asterisk may have an (R) or an (S) configuration;
- and wherein R1 and R2 are fluoro.
A kit comprising a pharmaceutical composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof:
- wherein the carbon marked by an asterisk may have an (R) or an (S) configuration;
- and wherein R1 and R2 are fluoro;
- and a pharmaceutically acceptable excipient.
A method for inhibiting cytidine deaminase, comprising administering to a subject in need a composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof:
- wherein the carbon marked by an asterisk may have an (R) or an (S) configuration;
- and wherein R1 and R2 are fluoro;
- and a pharmaceutically acceptable excipient.
A method for inhibiting degradation of a CDA substrate drug by cytidine deaminase, comprising administering to a subject that is undergoing treatment with the CDA substrate drug a composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof:
- wherein the carbon marked by an asterisk may have an (R) or an (S) configuration;
- and wherein R1 and R2 are fluoro;
- and a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.