Metallothionein-derived peptide fragments
AssigneeUniversity of Tasmania
InventorsVladimir Berezin, Elisabeth Bock, Milena Penkowa
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Abstract
The present invention relates to neural cell survival, differentiation and proliferation promoting peptide fragments derived from metallothioneins (MT), pharmaceutical compositions comprising said peptide fragments and uses thereof for treatment of diseases and conditions where the effects of stimulating neural cell proliferation, differentiation and/or survival, and/or stimulating neural plasticity associated with learning and memory are beneficial for treatment.
Claims32
A peptide having a length of from 13 to 17 amino acids, wherein the peptide comprises the amino acid sequence AQGSICKGASDKSS (SEQ ID NO:5) or a variant of SEQ ID NO:5, said variant having at least 65% sequence identity to SEQ ID NO:5, and wherein the peptide stimulates neurite outgrowth, neural cell survival, neural cell differentiation, and/or neural plasticity associated with learning and memory, and/or inhibits inflammation.
A pharmaceutical composition comprising a peptide having a length of from 13 to 17 amino acids, wherein the peptide comprises the amino acid sequence AQGSICKGASDKSS (SEQ ID NO:5) or a variant of SEQ ID NO:5, said variant having at least 65% sequence identity to SEQ ID NO:5, and wherein the peptide stimulates neurite outgrowth, neural cell survival, neural cell differentiation, and/or neural plasticity associated with learning and memory, and/or inhibits inflammation.
A pharmaceutical composition comprising a peptide having a length of from 13 to 20 amino acids, wherein the peptide comprises the amino acid sequence AQGSICKGASDKSS (SEQ ID NO:5) or a variant of SEQ ID NO:5, said variant having at least 90% sequence identity to SEQ ID NO:5, and wherein the peptide stimulates neurite outgrowth, neural cell survival, neural cell differentiation, and/or neural plasticity associated with learning and memory, and/or inhibits inflammation.
Dependencies are inferred from the claim text.