Peptide composition for cancer treatment by inhibiting TRPV6 calcium channel activity
AssigneeSoricimed Biopharma Inc.
InventorJohn M. Stewart
Life of this patent
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Abstract
The invention includes an isolated peptide comprising all or part of the amino acid sequence: EGKLSSNDTE GGLCKEFLHP SKVDLPR (SEQ ID NO: 1), wherein the peptide inhibits calcium channel activity. The peptides of the invention are useful for preventing or treating cancer.
Claims18
A method of inhibiting calcium uptake by a cancer cell to reduce cell proliferation, comprising administering to the cell a peptide consisting of fewer than 35 amino acids and comprising an amino acid sequence with at least 80% sequence identity to amino acid residues at positions 15 to 27 of SEQ ID NO:
- 1 (KEFLHPSKVDLPR) wherein the peptide inhibits calcium uptake by the cancer cell without paralytic activity.
A method of treating cancer in an animal in need thereof, comprising administering to the animal in need thereof a peptide consisting of fewer than 35 amino acids and comprising an amino acid sequence with at least 80% sequence identity to amino acid residues at positions 15 to 27 of SEQ ID NO:
- 1 (KEFLHPSKVDLPR), wherein the peptide inhibits calcium channel activity without paralytic activity.
A method of treating cancer in an animal in need thereof, comprising administering to the animal a peptide consisting of the amino acid sequence at positions 15 to 27 of SEQ ID NO:
- 1 (KEFLHPSKVDLPR).
Dependencies are inferred from the claim text.