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US 8,618,056 B2Granted
Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
OwnerCuthbert O. Simpkinsinventor
Life of this patent
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Abstract
A pharmaceutical composition comprising a lipid component; an amphiphilic emulsifier; and a polar liquid carrier. The lipid component and the amphiphilic emulsifier form free-moving lipid-carrying micelles (LMs) in the polar liquid carrier. The pharmaceutical composition is free of hemoglobin and fluorocarbon and can be used for treating conditions related to lack of blood supply and to raise the blood pressure.
Claims17
A method for raising blood pressure in a subject, comprising:
- infusing into said subject, an effective amount of a pharmaceutical composition comprising:
- a lipid component;
- an amphiphilic emulsifier;
- and
- a polar liquid carrier,
- wherein the lipid component and the amphiphilic emulsifier form free-moving lipid-carrying micelles (LM) in the polar liquid carrier, wherein the pharmaceutical composition is free of hemoglobin and fluorocarbon, and wherein said pharmaceutical composition is infused in an amount that equals to, or is greater than, 10% of the normal blood volume of said subject.
3 more elements
A method for treating a shock patient, comprising:
- (a) infusing into said patient, an effective amount of a first pharmaceutical composition comprising:
- a first lipid component comprising soy bean oil;
- a first amphiphilic emulsifier;
- and
- a first polar liquid carrier,
- wherein the first lipid component and the first amphiphilic emulsifier form free-moving lipid-carrying micelles (LM) in the first polar liquid carrier, wherein the first pharmaceutical composition is free of hemoglobin and fluorocarbon;
- and
- (b) infusing into said patient, an effective amount of a second pharmaceutical composition comprising:
- a second lipid component comprising chia bean oil;
- a second amphiphilic emulsifier;
- and
- a second polar liquid carrier,
- wherein the second lipid component and the second amphiphilic emulsifier form free-moving LMs in the second polar liquid carrier, wherein the second pharmaceutical composition is free of hemoglobin and fluorocarbon.
10 more elements
Dependencies are inferred from the claim text.