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US 8,618,055 B2Granted
Prominin-1 peptide fragments and uses thereof
AssigneeChildren's Medical Center Corporation
InventorsAvner Adini, Robert D'Amato
Life of this patent
Estimating the term…
Abstract
Described herein are peptide compositions of a prominin-1, which have regenerative activity. As such the peptides are useful when regeneration is needed, for example, to enhance angiogenesis, increase VEGF binding to endothelial cells, promote vasodilation, enhance cell migration, enhance cell proliferation, stimulate neuronal growth, prevent neurodegeneration, and/or promote neuroregeneration.
Claims13
An isolated peptide comprising an amino acid sequence selected from the group consisting of:
- LCGNSFSGGQPS (SEQ ID NO:
- 4);
- PNIIPVLDEIKS (SEQ ID NO:
- 5);
- LCGVCGYDRHAT (SEQ ID NO:
- 6);
- DRVQRQTTTVVA (SEQ ID NO:
- 8);
- CSFAYDLEAKANSLPPGNLRN (SEQ ID NO:
- 9);
- and DRVQBQTTTVVA (SEQ ID NO:
- 54), wherein B is any one of the naturally occurring amino acids;
- and wherein the isolated peptide is no more than 50 amino acids in length.
10 more elements
An isolated peptide comprising an amino acid sequence consisting of:
- ITNNTSSVIIEE (SEQ ID NO:
- 7), wherein the isolated eptide is no more than 25 amino acids in length.
Dependencies are inferred from the claim text.