Treatment of atherosclerosis with cholesterol ester transport protein mimotopes
AssigneeAffiris AG
InventorsSylvia Brunner, Petra Luehrs, Frank Mattner, Walter Schmidt, Barbara Wittmann
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Abstract
The present invention relates to a method for treating atherosclerosis and/or atherosclerosis sequelae with a compound that includes FX8(F)oPX9HX10X11X12DX2X3X4X5X6X7 where X8 is G, A, F, Y or K, X9 is E, Y, A, Q, K or S, X10 is H, V, L, F or I, X11 is L, W, S, I, F or Y, X12 is V, T, F or I, X5 is S or Y, X6 is L, A or I, X7 is S, N or T, and o is 0 or 1.
Claims10
A method for treating at least one of atherosclerosis, and atherosclerosis sequelae, comprising administering to a subject in need thereof, an effective amount of a medicament comprising a compound, wherein the compound comprises the amino acid sequence
- (SEQ ID NO. 42)
- FX8(F)oPX9HX10X11X12DX2X3X4X5X6X7,
- wherein
- X8 is selected from the group consisting of G, A, F, Y and K,
- X9 is selected from the group consisting of E, Y, A, Q, K and S,
- X10 is selected from the group consisting of H, V, L, F and I,
- X11 is selected from the group consisting of L, W, S, I, F and Y,
- X12 is V, T, F or I,
- X5 is S or Y,
- X6 is L, A or I,
- X7 is S, N or T,
- o is 0 or 1
- X2 is an amino acid residue selected from the group consisting of F, W, and Q,
- X3 is L or S, and
- X4 is Q or H,
- wherein the compound does not comprise a 4 to 16 mer polypeptide sequence of the cholesterol ester transport protein (CETP) or a CETP epitope.
Dependencies are inferred from the claim text.