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US 8,618,045 B2Granted
Modified human tumor necrosis factor receptor-1 polypeptide or fragment thereof, and method for preparing same
AssigneeHanall Biopharma Co., Ltd.
InventorsSung Wuk Kim, Sung Soo Jun, Seung Kook Park, Song Young Kim, Eun Sun Kim, Jae Kap Jeong, Ha Na Kim, Yeon Jung Song
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Abstract
Provided is a modified human tumor necrosis factor receptor-1 polypeptide or a fragment thereof that binds to a tumor necrosis factor in vivo or ex vivo. The modified human tumor necrosis factor receptor-1 polypeptide or fragment exhibits improved ability to bind tumor necrosis factor and resistance to proteases.
Claims23
A modified tumor necrosis factor receptor-1 polypeptide, comprising an amino acid sequence selected from the group consisting of:
- an amino acid sequence comprising modifications of 5 amino acid residues consisting of 4 amino acid residues at positions 92, 95, 97 and 98, and 1 amino acid residue at one selected from among positions 68, 161, 200 and 207 in an amino acid sequence of a wild-type tumor necrosis factor receptor-1 polypeptide represented by SEQ ID NO:
- 1;
- an amino acid sequence comprising modifications of 5 amino acid residues consisting of 4 amino acid residues at positions 92, 95, 97 and 98, and 1 amino acid residue at one selected from among positions 68, 161, 200 and 207 in an amino acid sequence (TNFRI171) consisting of amino acids 41-211 of an amino acid sequence of a wild-type tumor necrosis factor receptor-1 polypeptide represented by SEQ ID NO:
- 1;
- an amino acid sequence comprising modifications of 5 amino acid residues consisting of 4 amino acid residues at positions 92, 95, 97 and 98, and 1 amino acid residue at one selected from among positions 68 and 161 in an amino acid sequence (TNFRI126) consisting of amino acids 41-166 of an amino acid sequence of a wild-type tumor necrosis factor receptor-1 polypeptide represented by SEQ ID NO:
- 1;
- and
- an amino acid sequence comprising modifications of 5 amino acid residues at positions 68, 92, 95, 97 and 98 in an amino acid sequence (TNFRI105) consisting of amino acids 41-145 of an amino acid sequence of a wild-type tumor necrosis factor receptor-1 polypeptide represented by SEQ ID NO:
- 1.
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