Polymer having visibility in magnetic resonance image and surface lubricity and medical device
AssigneeTerumo Kabushiki Kaisha
InventorTomoka Kurita
Life of this patent
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Abstract
Provided are a polymer which, when wetted, enables a medical apparatus for use in MRI diagnosis and therapy to be easily visible under MRI and, simultaneously, develops surface lubricity, and a medical apparatus coated with the polymer. The polymer including a copolymer composed of a substance for shortening relaxation time of a nuclear species capable of being detected by magnetic resonance, a moiety having a reactive group, and a moiety for developing lubricity is used to coat the medical apparatus, whereby excellent peel resistance, high lubricity, visibility under magnetic resonance, easy applicability, and high safety can be obtained.
Claims13
A medical apparatus, comprising a substrate surface that is coated with a coating formed from a block copolymer comprising a moiety having a reactive group which is an epoxy group;
- and a moiety for developing lubricity comprising a hydrophilic monomer or a repetition of said monomer,
- wherein a substance for shortening relaxation time of a nuclear species capable of being detected by magnetic resonance is chemically bound to an epoxy group of the block copolymer,
- wherein the block copolymer is directly attached to the substrate surface of the medical apparatus,
- wherein the molar ratio of the moiety having a reactive group to the moiety for developing lubricity is 1:3 to 1:19,
- wherein said copolymer, when wetted, develops surface lubricity and MRI visibility,
- wherein either one of said moieties and said substance for shortening said relaxation time are covalently bound to each other either directly or through a linker molecule, and
- wherein said linker molecule is at least one selected from the group consisting of a diamine, amino-alcohol, dialkylenetriamine, aminocarboxylic acid, lactam, diol, hydroxycarboxylic acid, dicarboxylic acid, diisocyanate, diisothiocyanate, aminoisocyanate, aminoisothiocyanate, hydroxylisocyanate, hydroxylisothiocyanate, carboxylisocyanate, and carboxylisothiocyanate.
A medical apparatus, comprising a substrate surface that is coated with a coating formed from a block copolymer comprising a moiety having a reactive group which is an epoxy group, and a moiety for developing lubricity comprising a hydrophilic monomer or a repetition of said monomer,
- wherein a substance for shortening relaxation time of a nuclear species capable of being detected by magnetic resonance is chemically bound to the moiety for developing lubricity,
- wherein the block copolymer is directly attached to the substrate surface of the medical apparatus,
- wherein the molar ratio of the moiety having a reactive group to the moiety for developing lubricity is 1:3 to 1:19;
- wherein said copolymer, when wetted, develops surface lubricity and MRI visibility,
- wherein either one of said moieties and said substance for shortening said relaxation time are covalently bound to each other either directly or through a linker molecule, and
- wherein said linker molecule is at least one selected from the group consisting of a diamine, amino-alcohol, dialkylenetriamine, aminocarboxylic acid, lactam, diol, hydroxycarboxylic acid, dicarboxylic acid, diisocyanate, diisothiocyanate, aminoisocyanate, aminoisothiocyanate, hydroxylisocyanate, hydroxylisothiocyanate, carboxylisocyanate, and carboxylisothiocyanate.
A medical apparatus, comprising a substrate surface that is coated with a coating formed from a block copolymer comprising a moiety having a reactive group which is an epoxy group;
- and a moiety for developing lubricity comprising a hydrophilic monomer or a repetition of said monomer,
- wherein a substance for shortening relaxation time of a nuclear species capable of being detected by magnetic resonance is chemically bound to an epoxy group of the block copolymer,
- wherein the block copolymer is directly attached to the substrate surface of the medical apparatus,
- wherein said copolymer, when wetted, develops surface lubricity and MRI visibility,
- wherein either one of said moieties and said substance for shortening said relaxation time are covalently bound to each other either directly or through a linker molecule, and
- wherein said linker molecule is at least one selected from the group consisting of a diamine, amino-alcohol, dialkylenetriamine, aminocarboxylic acid, lactam, diol, hydroxycarboxylic acid, dicarboxylic acid, diisocyanate, diisothiocyanate, aminoisocyanate, aminoisothiocyanate, hydroxylisocyanate, hydroxylisothiocyanate, carboxylisocyanate, and carboxylisothiocyanate.
A medical apparatus, comprising a substrate surface that is coated with a coating formed from a block copolymer comprising a moiety having a reactive group which is an epoxy group, and a moiety for developing lubricity comprising a hydrophilic monomer or a repetition of said monomer,
- wherein a substance for shortening relaxation time of a nuclear species capable of being detected by magnetic resonance is chemically bound to the moiety for developing lubricity,
- wherein the block copolymer is directly attached to the substrate surface of the medical apparatus,
- wherein said copolymer, when wetted, develops surface lubricity and MRI visibility,
- wherein either one of said moieties and said substance for shortening said relaxation time are covalently bound to each other either directly or through a linker molecule, and
- wherein said linker molecule is at least one selected from the group consisting of a diamine, amino-alcohol, dialkylenetriamine, aminocarboxylic acid, lactam, diol, hydroxycarboxylic acid, dicarboxylic acid, diisocyanate, diisothiocyanate, aminoisocyanate, aminoisothiocyanate, hydroxylisocyanate, hydroxylisothiocyanate, carboxylisocyanate, and carboxylisothiocyanate.
Dependencies are inferred from the claim text.