Determining the presence or amount of a metal-labelled species
AssigneeAlere Switzerland GmbH
InventorsBrian Jeffrey Birch, Camilla Sofia Forssten, Alena Kabil, Robert Andrew Porter
Life of this patent
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Abstract
A method for determining the presence or amount of a metal-labelled species in a sample may include causing the metal of the metal-labelled species in the sample to form a soluble electrochemically-active complex which is stable relative to moieties present or potentially present in the sample which will form an insoluble and/or electrochemically-inactive complex with the metal, and electrochemically measuring the formed complex to provide an indication of the presence or amount of the metal-labelled species.
Claims6
A method for determining the presence or amount of a silver-labelled species in a sample, the method comprising:
- applying the sample to a test device in a dry state, the test device comprising dried reagents;
- causing the metal of the silver-labelled species in the sample to form a soluble electrochemically-active complex which is stable relative to moieties present or potentially present in the sample which moieties will form an insoluble and/or electrochemically-inactive complex with the silver, wherein the electrochemically-active complex is formed by oxidising the silver to form a silver ion and reacting the silver ion with a complexing agent according to the following reaction:
- Ag++m(NH4)++n(SCN)−→[Ag(NH4)+m(SCN−)n]m-n+1;
- and
- electrochemically measuring the formed complex to provide an indication of the presence or amount of the silver-labelled species.
Dependencies are inferred from the claim text.