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US 8,617,887 B2Granted
Method of generating oligodendrocytes from neurosphere cells
AssigneeYeda Research and Development Co. Ltd.
InventorsMichel Revel, Judith Chebath, Peter Lonai
Life of this patent
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Abstract
The present invention is generally in the field of neurological diseases and disorders, particular in the field of neurodegenerative diseases in which the myelin cover of nerves is lost. IL6R/IL6 chimera is used to promote the formation of oligodendrocytes from embryonic stem cells for treatment of neurodegenerative diseases or posttraumatic nerve damage.
Claims11
A method for generating O1+ and/or O4+ oligodendrocytes, said method comprising
- growing neurosphere (NS) cells in a culture medium that promotes preferential differentiation of NS cells into O1+ and/or O4+ oligodendrocytes,
- said culture medium comprising one or more, IL6R/IL6 chimeras, and
- wherein said culture medium specifically enhances differentiation into the O1+ and/or O4+ oligodendrocyte lineage, thereby causing the NS cells to preferentially differentiate along the oligodendrocyte lineage into O1+ and/or O4+ oligodendrocytes.
Dependencies are inferred from the claim text.