Cardiac stem cell and myocyte secreted paracrine factors
AssigneeThe Johns Hopkins University
InventorsEduardo Marban, Jennifer E. Van Eyk
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Abstract
The invention relates to secreted proteins from cardiac stem cells (cardiospheres and cardiosphere-derived cells) or myocytes for diagnostic and/or therapeutic use.
Claims4
A method for screening a cardiac patient as a candidate for stem cell therapy, said method comprising measuring in a biological sample from the patient the amount of apolipoprotein E precursor, atriopeptigen (ANP, ANF), adrenomedullin, brain acid soluble protein 1 (BASP 1 protein), cathepsin B precursor, collagen alpha-1 (VI) chain precursor, connective tissue growth factor, cystatin E/M, Dkk3 protein, insulin-like growth factor-binding protein 2 precursor, interleukin-1 receptor-like 1 precursor (ST2), matrix metallopeptidase 2, metalloproteinase inhibitor 1 precursor (TIMP-1), metalloproteinase inhibitor 2 precursor (TIMP-2), mimecan precursor, procollagen type III alpha 1, procollagen type V alpha 1 and tropoelastin, comparing said measurement to a baseline value, wherein a statistically significant amount of the protein(s) compared to the baseline value indicates that the patient would be likely to benefit from stem cell therapy.
Dependencies are inferred from the claim text.