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US 8,617,875 B2Granted
Expression vector suitable for expression of a coding sequence for gene therapy
AssigneeMogam Biotechnology Research Institute
InventorsDaekyung Koh, Kyuhyun Lee, Hyeon Lee, Seongtae Yun, Eui-Cheol Jo
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Abstract
Provided is an expression vector for gene therapy having a novel combination of transcriptional regulatory elements, including a promoter, an enhancer, an intron, an untranslated region (UTR) and a locus control region (LCR). The expression vector enables sustained expression of a liver tissue-specific gene, and thus, can be effectively used for treating thrombosis, hemophilia, liver cancer, etc.
Claims19
An isolated polynucleotide consisting of the nucleotide sequence as set forth in SEQ ID NO:
- 52.
An expression cassette comprising:
- a promoter;
- a coding sequence operably linked to and under control of the promoter;
- and
- an intron consisting of the nucleotide sequence as set forth in SEQ ID NO:
- 52, said intron being operably linked to the coding sequence.
2 more elements
Dependencies are inferred from the claim text.