US 8,617,872 B2 · Compositions for culturing spirochetes

Abstract

The present invention relates to methods and compositions for culturing spirochetes and treating spirochetal diseases. For example, the present invention provides serum-free media for culturing spirochete bacteria in vitro. The present invention further provides methods for identifying spirochete susceptibilities to antimicrobials and antimicrobial compositions and cocktails. The present invention also provides methods for treating subjects suspected of having a spirochete infection.

Claims13

Dependent claims

A composition comprising:

a) serum-free culture media comprising carbohydrates, salts, a source of nitrogen, metallic cations, growth factors, neural components, amino acids, and lipids;
b) a spirochete organism in said serum-free culture media;
and c) one or more antimicrobial agents suspected of being an antispirochete antimicrobial agents.

Dependencies are inferred from the claim text.

Facts

Application

13/083,239Filed 8 Apr 2011 · continuation

Priority

14 Apr 2000

Published

US 2011/0256612 A120 Oct 2011

Granted

31 Dec 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
C12N 1/20
Microorganisms; Compositions thereof ; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of…:…
C12Q 1/04
Involving viable microorganisms: determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides;…
C12Q 1/18
Involving viable microorganisms: testing for antimicrobial activity of a material

Family

Application09/550,025Parent of this continuation · filed 14 Apr 2000

Application11/768,408Parent of this continuation · filed 26 Jun 2007

US 7,235,397 B1Parent of this continuation · filed 26 Jun 2007

US 2011/0256612 A1Pre-grant publication · published 20 Oct 2011

US 7,932,076 B2Parent of this continuation

US 2009/0053796 A1Published application

US 8,617,872 B2This patent

From the US filing history. Foreign family members aren’t listed.

Abstract

Facts

Application

13/083,239Filed 8 Apr 2011 · continuation

Priority

14 Apr 2000

Published

US 2011/0256612 A120 Oct 2011

Granted

31 Dec 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 45/06
Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00: mixtures of active ingredients without…
C12N 1/20
Microorganisms; Compositions thereof ; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of…:…
C12Q 1/04
Involving viable microorganisms: determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides;…
C12Q 1/18
Involving viable microorganisms: testing for antimicrobial activity of a material

Family

Application09/550,025Parent of this continuation · filed 14 Apr 2000

Application11/768,408Parent of this continuation · filed 26 Jun 2007

US 7,235,397 B1Parent of this continuation · filed 26 Jun 2007

US 2011/0256612 A1Pre-grant publication · published 20 Oct 2011

US 7,932,076 B2Parent of this continuation

US 2009/0053796 A1Published application

US 8,617,872 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compositions for culturing spirochetes

Life of this patent

Abstract

Claims13

Compositions for culturing spirochetes

Life of this patent

Abstract

Claims13