Nucleic acids encoding antibody molecules which bind IL-17A and IL-17F
AssigneeUCB Pharma S.A.
InventorsRalph Adams, Andrew George Popplewell, Stephen Edward Rapecki
Life of this patent
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Abstract
The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Claims17
An isolated DNA molecule encoding a neutralising antibody which binds human IL-17A and human IL-17F, wherein the variable domain of the heavy chain comprises the sequence given in SEQ ID NO:
- 1 for CDR-H1, the sequence given in SEQ ID NO:
- 2 for CDR-H2 and the sequence given in SEQ ID NO:
- 3 for CDR-H3, and wherein the variable domain of the light chain comprises the sequence given in SEQ ID NO:
- 4 for CDR-L1, the sequence given in SEQ ID NO:
- 5 for CDR-L2 and the sequence given in SEQ ID NO:
- 6 for CDR-L3, or an antigen-binding fragment thereof.
An isolated DNA molecule encoding a neutralising antibody which binds human IL-17A and human IL-17F, wherein the heavy chain comprises the sequence given in SEQ ID NO:
- 9 and wherein the light chain comprises the sequence given in SEQ ID NO:
- 7, or an antigen-binding fragment thereof.
An isolated DNA molecule encoding a neutralising antibody which binds human IL-17A and human IL-17F, wherein the heavy chain comprises the sequence given in SEQ ID NO:
- 15 and wherein the light chain comprises the sequence given in SEQ ID NO:
- 11, or an antigen-binding fragment thereof.
An isolated DNA molecule encoding a neutralising antibody which binds human IL-17A and human IL-17F, wherein the heavy chain comprises the sequence given in SEQ ID NO:
- 9.
An isolated DNA molecule encoding a neutralising antibody which binds human IL-17A and human IL-17F, wherein the light chain comprises the sequence given in SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.