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US 8,617,828 B2Granted
Glutathione S-transferase omega 1 wild type specific antibody
AssigneeRandox Laboratories Limited
InventorsPeter Stephen Fitzgerald, Ivan Robert McConnell, Philip Andrew Lowry, Elouard Benchikh
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Abstract
The invention relates to a novel antibody which binds to wild type (wt) Glutathione S-transferase Omega 1 (wtGSTO1) but not to mutant (mut) GSTO1 and methods and uses based on the antibody. The antibody is based on novel haptens and immunogens.
Claims15
A polypeptide hapten having a structure selected from the group consisting of
- (SEQ ID NO:
- 2)
- Cys-Lys-Glu-Asp-Tyr-Ala-Gly-Leu-Lys;
- and
- (SEQ ID NO 6)
- Lys-Glu-Asp-Tyr-Ala-Gly-Leu-Lys-Cys;
- wherein a crosslinking group is attached to the sulphur atom of Cys.
4 more elements
Dependencies are inferred from the claim text.