Organ transplant solutions and method for transplanting organs
AssigneeChildren's Hospital Medical Center
InventorsJörg Köhl, Prasad Devarajan
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Abstract
A preservation solution for organs waiting to be transplanted is disclosed; the method of using the solution in a transplantation procedure is also disclosed. The preservation solutions comprise a balanced isotonic aqueous solution comprising sodium, potassium, calcium, magnesium and bicarbonate ions in a physiologically acceptable amount, together with an effective amount of a mutein of the C5a anaphylatoxin which is a C5a receptor antagonist wherein the amino acid residue naturally occurring at sequence position 69 is mutated.
Claims19
A preservation solution for storage and reperfusion of organs for implantation comprising:
- (a) a balanced isotonic solution comprising sodium, potassium, calcium, and magnesium ions, and glucose and sodium bicarbonate, in a physiologically acceptable amount;
- (b) a safe and effective amount of a C5a receptor antagonist comprising a mutein of the C5a anaphylatoxin, wherein the amino acid residue at sequence position 69 is mutated;
- and (c) water.
Dependencies are inferred from the claim text.