Sn-2 myristate-containing edible oil
AssigneeBrandeis University
InventorsDaniel Perlman, Kenneth C. Hayes
Life of this patent
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Abstract
A nutritional fat or oil-based composition for increasing HDL cholesterol, decreasing LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma is described. The composition can advantageously include at least 1% by weight myristic acid esterified at the sn-2 position in triglyceride molecules, includes between 10% and 40% by weight linoleic acid, and further includes between 30% and 65% by weight oleic acid and between 15% and 40% by weight total saturated fatty acids. The ratio of sn-2 myristic acid to sn-2 palmitic acid is typically greater than 1:1 and the sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%. In desirable cases, the composition is substantially cholesterol-free.
Claims13
An edible fat composition comprising at least 1% by weight myristic acid esterified at the sn-2 position in triglyceride molecules;
- between 10% and 40% by weight linoleic acid;
- between 30% and 65% by weight oleic acid;
- and
- between 15% and 40% by weight saturated fatty acids in toto, wherein the weight ratio of sn-2 myristic acid to sn-2 palmitic acid is at least 1:1, the sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%;
- and wherein consistent ingestion of said edible fat increases HDL cholesterol, decreases LDL cholesterol and decreases the LDL/HDL cholesterol ratio in human plasma.
A method of preparing a substantially cholesterol-free, edible fat composition, comprising blending a substantially cholesterol-free edible oil rich in sn-2 myristate with at least one other substantially cholesterol-free edible oil, thereby forming a blended edible oil comprising at least 1% by weight myristic acid esterified at the sn-2 position in triglyceride molecules, between 10% and 40% by weight linoleic acid, between 30% and 65% by weight oleic acid, and between 15% and 40% by weight total saturated fatty acids, wherein the ratio of sn-2 myristic acid to sn-2 palmitic acid is greater than 1:1, and the sum of weight percentages for saturated, polyunsaturated and monounsaturated fatty acids equals 100%.
An edible fat composition comprising
- at least 1% by weight myristic acid esterified at the sn-2 position in triglyceride molecules;
- between 10% and 40% by weight of at least two polyunsaturated fatty acids selected from the group consisting of linoleic acid, alpha-linolenic acid, EPA, DHA, and combinations thereof;
- between 30% and 65% by weight oleic acid;
- and
- between 15% and 40% by weight saturated fatty acids in toto, wherein the weight ratio of sn-2 myristic acid to sn-2 palmitic acid is at least 1:1, the sum of weight percentages for saturated, monounsaturated and polyunsaturated fatty acids equals 100%;
- and wherein consistent ingestion of said edible fat increases HDL cholesterol, decreases LDL cholesterol and decreases the LDL/HDL cholesterol ratio in human plasma.
Dependencies are inferred from the claim text.