Topical compositions containing magaldrate

#This is a National Stage of International Application PCT/M2008/002047, filed 28 Mar. 2008, which claims the benefit of Application No. MI2007A644, filed in Italy on 29 Mar. 2007, the disclosures of which Applications are incorporated by reference herein.

#This invention relates to topical compositions containing magaldrate which are useful to regenerate skin tissue in the treatment of some diseases of the skin and the nasal, vaginal and rectal mucous membranes. In particular, the compositions according to the invention are useful in the treatment and prophylaxis of irritative and inflammatory states of the skin, and as wound-healing agents.

#Magaldrate is a substance deriving from the combination of aluminium hydroxide and magnesium hydroxide, corresponding to the formula Al5 Mg10 (OH)31 (SO4)2×H2O, with a molecular weight of approx. 1097. Magaldrate is described as a white, crystalline powder insoluble in water and alcohol; the dry base contains 34-46% magnesium oxide, 21-30% aluminium oxide and 13.3-17.5% sulphur trioxide.

#It has now been found that topical magaldrate exerts a regenerating and anti-inflammatory action on the damaged epidermis, e.g. in the case of ulcers, venous ulcers, superficial ulcers, wounds, burns, eczema, rashes, psoriasis, ulcers, venous ulcers, superficial ulcers, wounds, burns, eczema, rashes, psoriasis, cutaneous lesions, diabetic lesions, traumatic lesions, surgical wounds, abrasions, dermatitis, macerations, stoma skin complications, inflammatory and/or infective skin disorders.

#The present invention therefore relates to topical compositions of magaldrate suitable for application to the skin and the nasal, vaginal and rectal mucous membranes.

#Examples of suitable carriers include native collagen, particularly native collagen type i, ii and iii from any source such as equine, bovine, porcine or aviarian collagen, vegetal collagen, hydrolyzed collagen, synthetic collagen. collagen may be in lyophilised or gel form. hyaluronic acid or derivatives thereof such as sodium hyaluronate, in crystalline form or in solution, as well as alginates may be conveniently used as carriers for magaldrate.