Charged lipoprotein complexes and their uses
OwnerJean-Louis Dasseuxinventor
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Abstract
The present disclosure provides charged lipoprotein complexes that include as one component a negatively charged phospholipid that is expected to impart the complexes with improved therapeutic properties.
Claims59
A charged lipoprotein complex comprising an apolipoprotein fraction and a lipid fraction, wherein said apolipoprotein fraction comprises at least one apolipoprotein and said lipid fraction consists essentially of (a) sphingomyelin, (b) about 0.2 to 3 wt % of one or more negatively charged phospholipids, and, optionally, (c) lecithin.
A method of treating dyslipidemia or a disease associated with dyslipidemia in a subject, comprising administering to a subject in need thereof an effective amount of a lipoprotein complex according to any one of 1, 16, 21, 25 and 31.
Dependencies are inferred from the claim text.