Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
AssigneeCordis Corporation
InventorsRobert Burgermeister, Vipul Dave
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Abstract
The present invention relates to a drug-containing polymeric composition comprising at least one therapeutic agent encapsulated in at least one biocompatible polymer, wherein at least a portion of the therapeutic agent in this polymeric composition is crystalline. The at least one biocompatible polymer may form a substantially continuous polymeric matrix with the at least one therapeutic agent encapsulated therein. Alternatively, the at least one biocompatible polymer may form polymeric particles with the at least one therapeutic agent encapsulated therein.
Claims13
A method for forming a drug-containing polymeric composition, said method comprising:
- forming crystalline particles of at least one therapeutic agent;
- and encapsulating said crystalline particles into at least one biocompatible polymer to form a drug-containing polymeric composition,
- wherein at least a portion of said crystalline particles remain crystalline in the drug-containing polymeric composition, and
- wherein the crystalline particles are first individually coated by a protective coating material, and then encapsulated into the at least one biocompatible polymer by a process that uses a polymeric solution, wherein said polymeric solution comprises the at least one biocompatible polymer dissolved in a solvent system comprising at least one solvent, and wherein the protective coating material is insoluble in said solvent system.
Dependencies are inferred from the claim text.