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US 8,617,604 B2Granted
Pharmaceutical compositions with enhanced performance
AssigneeBend Research, Inc.
InventorsWalter Christian Babcock, Dwayne Thomas Friesen, David Kenneth Lyon, Warren Kenyon Miller, Daniel Tod Smithey
Life of this patent
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Abstract
Pharmaceutical compositions of a low-solubility drug and lower alkanoate-, phthalate- and trimellitate esters of hydroxypropyl methyl cellulose and lower alkanoate- and succinate esters of cellulose and methyl cellulose are disclosed that provide enhanced concentrations of the drug in a use environment.
Claims8
A composition comprising
- (a) a low-solubility drug, said drug having a minimum aqueous solubility of 0.5 mg/mL or less, and
- (b) a cellulose alkanyl succinate polymer having a degree of substitution of alkanyl groups of at least 1.0 and a degree of substitution of succinyl groups of at least 0.2;
- wherein said polymer and said drug are in the form of a solid amorphous dispersion.
A composition comprising
- (a) a low-solubility drug, said drug having a minimum aqueous solubility of 0.5 mg/mL or less, and
- (b) a methyl cellulose alkanyl succinate polymer having a combined degree of substitution of methoxy groups and alkanyl groups of at least 1.0 and a degree of substitution of succinyl groups of at least 0.2;
- wherein said polymer and said drug are in the form of a solid amorphous dispersion.
Dependencies are inferred from the claim text.