Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response
AssigneeGenocea Biosciences, Inc.
InventorsDeborah Long, Jessica Flechtner, Mojca Skoberne, George R. Siber
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Abstract
Herpes Simplex Virus-2 (HSV-2) infection is a major health concern. The present disclosure provides, inter alia, certain highly effective vaccines and immunogenic compositions against HSV-2. The antigens can be used therapeutically or prophylactically.
Claims30
A vaccine formulation comprising a pharmaceutically-acceptable carrier and an HSV-2 gD2 polypeptide, wherein the gD2 polypeptide has an internal deletion of all or part of a transmembrane domain.
A vaccine formulation comprising a pharmaceutically-acceptable carrier and a polypeptide comprising the amino acid sequence of SEQ ID NO:5 having an internal deletion of 8-23 contiguous amino acid residues selected from amino acid residues 340-363 of SEQ ID NO:5.
A vaccine formulation comprising a pharmaceutically acceptable carrier and a polypeptide comprising the amino acid sequence of SEQ ID NO:4.
A vaccine formulation comprising a pharmaceutically-acceptable carrier and a polypeptide comprising the amino acid sequence of SEQ ID NO:4 having a deletion of 1-20 amino acid residues at the N-terminus, C-terminus, or both, of SEQ ID NO:4.
A vaccine formulation comprising a pharmaceutically-acceptable carrier, an adjuvant comprising one or more purified fractions of quillaja saponins, a first polypeptide comprising the amino acid sequence of SEQ ID NO:4 and a second polypeptide comprising the amino acid sequence of SEQ ID NO:1 or an immunogenic fragment comprising at least 8 contiguous amino acids of SEQ ID NO:1.
A vaccine formulation comprising a pharmaceutically-acceptable carrier, a first polypeptide comprising the amino acid sequence of SEQ ID NO:4, and a second polypeptide comprising the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.