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US 8,617,547 B2Granted
Methods and compositions for diagnosing prostate cancer
AssigneeThe Regents of the University of Michigan
InventorsArul Chinnaiyan, David Beer, Guoan Chen, Xiaoju Wang
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Abstract
The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to ubiquilin 1 markers for cancer.
Claims22
A method for detecting prostate cancer, comprising:
- a. detecting in a sample from a subject an expression level of an autoantibody to an antigen derived from FAM53B, 5′UTR-BMI, alpha-2-glycoprotein 1, or DCAMKL1;
- and,
- b. detecting prostate cancer in said subject when said autoantibody to said antigen is overexpressed in said sample.
A method for detecting prostate cancer, comprising:
- a. detecting in a sample from a subject a presence or absence of an autoantibody to an antigen derived from FAM53B, 5′UTR-BMI, alpha-2-glycoprotein 1, or DCAMKL1;
- and,
- b. detecting prostate cancer in said subject when said autoantibody to said antigen is present in said sample.
A method for detecting prostate cancer in a subject comprising:
- a. obtaining a serum or blood sample from said subject;
- b. detecting in said serum or blood sample the presence or expression level of an autoantibody to an antigen derived from FAM53B, 5′UTR-BMI, alpha-2-glycoprotien 1, or DCAMKL1 by binding said autoantibody to an antigen in an array of antigens;
- and
- c. detecting the presence of prostate cancer in said subject when said autoantibody to said antigen derived from FAM53B, 5′UTR-BMI, alpha-2-glycoprotien 1, or DCAMKL1 is present or overexpressed in said serum or blood sample.
1 more element
Dependencies are inferred from the claim text.