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US 8,617,534 B2Granted
Compositions and method for manipulating PIM-1 activity in circulatory system cells
AssigneeSan Diego State University (SDSU) Foundation
InventorsMark A. Sussman, John A. Muraski
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Abstract
The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding the serine/threonine kinase PIM-1, and methods for making and using them; including methods for inducing cellular proliferation, and protecting cardiac cells from hypoxia and cellular apoptosis. The invention provides compositions (e.g., pharmaceutical compositions) comprising nucleic acids encoding PIM-1, and methods for enhancing the regenerative potential of stem cells in the heart.
Claims8
A method for treating a cardiac injury in an individual, comprising:
- introducing into the heart of the individual a population of autologous or allogeneic cardiac progenitor cells that have been engineered to contain an expression vector comprising a heterologous promoter operatively linked to a PIM-1 encoding polynucleotide sequence for overexpression of a PIM-1 kinase in the cardiac progenitor cells, wherein the introduced cardiac progenitor cells differentiate into functional cardiomyocytes in the heart in sufficient numbers to treat said cardiac injury.
Dependencies are inferred from the claim text.