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US 8,617,521 B2Granted
Phage antibodies to radiation-inducible neoantigens
AssigneeVanderbilt University
InventorsDennis E. Hallahan, Raymond Mernaugh
Life of this patent
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Abstract
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
Claims8
A method of detecting a tumor in a mammalian subject, the method comprising:
- (a) exposing a suspected tumor to ionizing radiation;
- (b) administering to the subject an immunoconjugate composition comprising a single chain fragment variable (scFv) antibody that binds to a radiation-inducible neoantigen derived from tumor vascular endothelium selected from the group consisting of P-selectin, E-selectin, endoglin, α2bβ3 integrin and αvβ3 integrin, or a Fab fragment thereof, conjugated to a detectable label;
- and (c) detecting the detectable label, whereby a tumor is detected.
Dependencies are inferred from the claim text.