Injectable cross-linked hydrogels for biomaterial applications
AssigneeDePuy Synthes Products, Inc.
InventorsValerie R. Binetti, Kristin B. Kita, Garland W. Fussell, Anthony M. Lowman, Michele S. Marcolongo
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Abstract
An injectable hydrogel composition comprising: water; and poly(vinyl alcohol) chemically cross-linked with a second polymer to form a cross-linked resin, wherein the second polymer is selected from the group consisting of: a polyhydric alcohol compound, a polyvalent epoxy compound, a polyvalent amine compound, a dialdehyde compound, a diisocyanate compound, and mixtures thereof, wherein the cross-linked resin has a degree of cross-linking of from about 0.0001 mol/mL to about 0.002 mol/mL, and wherein the hydrogel is flowable when heated above its melting point.
Claims21
An injectable hydrogel composition comprising:
- water;
- and
- poly(vinyl alcohol) chemically cross-linked with a second polymer to form a cross-linked resin, wherein the second polymer is selected from the group consisting of:
- a polyhydric alcohol compound, a polyvalent epoxy compound, a polyvalent amine compound, a dialdehyde compound, a diisocyanate compound, and mixtures thereof,
- wherein the cross-linked resin has a degree of chemical cross-linking of from about 0.0001 mol/mL to about 0.002 mol/mL, wherein the hydrogel is flowable when heated above its melting point, and wherein the hydrogel composition exhibits a swelling value of from about 1.033 to about 1.79 in a 0.16 MPa osmotic solution.
Dependencies are inferred from the claim text.