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US 8,617,517 B2Granted
Cromolyn derivatives and related methods of imaging and treatment
AssigneeThe General Hospital Corporation
InventorsDavid R. Elmaleh, Timothy Shoup
Life of this patent
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Abstract
Novel cromolyn analogs useful as imaging agents for detecting atherosclerotic plaques and for treating atherosclerosis and Alzheimer's Disease, and methods of making the cromolyn analogs, are disclosed. The cromolyn analogs have the general formula (I), or formula (II); wherein X is OH, C1-C6 alkoxyl, 18F, or 19F; Y and Z are independently selected from a C1-C6 alkyl, CpC6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H; and n is 1, 2, or 3; and wherein for structure (I), if n are both 1 and Y and Z are both H, X is not OH.
Claims9
A compound having the formula:
- or a salt or ester of (I) or (II);
- wherein:
- X is 18F, or 19F;
- Y and Z are independently selected from a C1-C6 alkyl, C1-C6 alkoxyl, halogen, un-substituted or C1-C6 substituted amine, 18F, 19F, or H;
- and
- n is 1, 2, or 3.
3 more elements
Dependencies are inferred from the claim text.