Universal anchor peptide for nanoparticles

A kit for preparing a nanoparticle comprising an anchor peptide, the kit comprising a first composition and a second composition, the first composition comprising a nanoparticle comprising a core encapsulated by a lipid layer, the second composition comprising the anchor peptide which is substantially non-lytic, non-cytotoxic, consists of an amino acid sequence selected from the group consisting of SEQ ID NOs:5-218, and has an association rate of at least about 9×105 M−1 s−1 and a dissociation constant of less than about 1×10−6 M.

A method for adding a cargo complex to a nanoparticle comprising a lipid layer, the method comprising contacting the nanoparticle with an anchor peptide that is conjugated to the cargo complex, the anchor peptide being substantially non-lytic, non-cytotoxic, and consisting of an amino acid sequence selected from the group consisting of SEQ ID NOs:5-218 with an association rate of at least about 9×105 M−1 s−1 and a dissociation constant of less than about 1×10−6 M, wherein the anchor peptide stably inserts into the lipid layer of the nanoparticle.